{"product_id":"thorne-5-hydroxytryptophan","title":"Thorne 5-HTP (formerly 5-Hydroxytryptophan)","description":"\u003cp\u003e\u003cstrong\u003e5-HTP (formerly 5-Hydroxytryptophan)\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eThe serotonin levels in the body are associated with the regulation of sleep, mood, and appetite.\u003c\/p\u003e\u003cp\u003eA balanced serotonin level has been shown to support restful sleep, good mood, and decreased sugar cravings. There are several ways to support a healthy serotonin level. L-tryptophan and 5-HTP (5-Hydroxytryptophan) are both precursors to serotonin. However, supplementation with 5-HTP is preferable, because unlike L-tryptophan, 5-HTP cannot be shunted into other uses in the body, such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system. And 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP (5-Hydroxytryptophan) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron. 5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream. Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue. Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily. To further facilitate serotonin production, Thorne's 5-HTP formula contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia. Each lot is thoroughly tested for contaminants, including Peak X, and is Peak X free. Show More Warnings ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY WARNING If pregnant or nursing, do not use this product. INTERACTIONS 5-H\u003c\/p\u003e","brand":"Thorne","offers":[{"title":"Default Title","offer_id":53270997238123,"sku":"SA503","price":30.9,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0971\/6423\/1019\/files\/sa503__vd9af7bad1918aceb7928aba34e5b60642bc538a1.png?v=1779440950","url":"https:\/\/esthena.ca\/products\/thorne-5-hydroxytryptophan","provider":"Esthena","version":"1.0","type":"link"}